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Latest papers and news related to RNA-Seq(Aug. 2026)

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Latest Papers(RNA-Seq Part)
1. Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis
Krzak M et al. Nat Genet. 2026 Jul;58(7):1610-1619. doi: 10.1038/s41588-026-02634-7. Epub 2026 Jun 15.
 
2. Mutation-specific dynamics of dedifferentiation trajectories and tumor-stromal interactions in thyroid cancer
Joo EH et al. Mol Cancer. 2026 Jul 16;25(1):175. doi: 10.1186/s12943-026-02699-2.
 
3. Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex
Shi S et al. Neuron. 2026 Jul 1;114(13):2456-2472.e7. doi: 10.1016/j.neuron.2026.02.017. Epub 2026 Mar 26.
 
4. Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism
Stupakov P et al. Gut. 2026 Jul 1:gutjnl-2025-337316. doi: 10.1136/gutjnl-2025-337316. Online ahead of print.
 
5. Molecular and Immune Landscape of Recurrent and/or Distant Metastatic Squamous Cell Carcinoma of the Head and Neck: An EORTC/IMMUCAN Project
van der Elst A et al. Clin Cancer Res. 2026 Jul 1;32(13):2732-2747. doi: 10.1158/1078-0432.CCR-25-3377.
 
6. Continuous modeling of primate embryogenesis from totipotency to early organogenesis
Zheng W et al. Cell. 2026 Jul 23;189(15):4664-4684.e9. doi: 10.1016/j.cell.2026.05.023. Epub 2026 Jun 10.
 
7. Spatial proximity sequencing maps developmental dynamics in the germinal center
Wang H et al. Cell. 2026 Jul 16:S0092-8674(26)00754-3. doi: 10.1016/j.cell.2026.06.034. Online ahead of print.
 
8. TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells
Wang Y et al. Nat Cell Biol. 2026 Jul;28(7):1480-1495. doi: 10.1038/s41556-026-01985-x. Epub 2026 Jun 11.
 
9. Connecting single-cell transcriptomes to projectomes in the mouse visual cortex
Sorensen SA et al. Nature. 2026 Jul 1. doi: 10.1038/s41586-026-10424-8. Online ahead of print.
 
10. The RNA-binding dynamics of the exon-junction complex underlying splicing-coupled RNA fate determination in arabidopsis
Sun K et al. Plant Cell. 2026 Jul 2;38(7):koag212. doi: 10.1093/plcell/koag212.
 
11. Single cell multiomics unravel the transcription networks controlling the different EMT tumor states
Pérez-González A et al. Nat Commun. 2026 Jul 11. doi: 10.1038/s41467-026-75521-8. Online ahead of print.
 
12. A systems-level atlas of carbon-response transcriptional states in Escherichia coli
Shin J et al. Proc Natl Acad Sci U S A. 2026 Jul 7;123(27):e2531884123. doi: 10.1073/pnas.2531884123. Epub 2026 Jul 1.
 
13. MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling
Chan TEH et al. Genes Dev. 2026 Jul 1;40(13-14):1012-1028. doi: 10.1101/gad.353313.125.
 
14. Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer
Wright SJ et al. Cell Rep Med. 2026 Jul 21;7(7):102910. doi: 10.1016/j.xcrm.2026.102910. Epub 2026 Jul 2.
 
15. SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice
Xiao C et al. Cell Death Differ. 2026 Jul 1. doi: 10.1038/s41418-026-01790-x. Online ahead of print.
 
16. Context-aware sequence-to-function model of human gene regulation
Aksu ED et al. Nat Commun. 2026 Jul 14;17(1):6200. doi: 10.1038/s41467-026-75527-2.
 
17. Reprogramming the pancreatic ductal adenocarcinoma microenvironment: a novel integrin-targeted cytotoxin, ProAgio, potentiates chemotherapy
Nagaraju GP et al. Mol Cancer. 2026 Jul 3. doi: 10.1186/s12943-026-02725-3. Online ahead of print.
 
18. Microglia-mediated protection against Alzheimer's disease pathology and detrimental effects in white matter revealed by Ptpn6 deletion
Etxeberria A et al. Neuron. 2026 Jul 1;114(13):2367-2385.e8. doi: 10.1016/j.neuron.2026.02.023. Epub 2026 Mar 26.
 
19. Embryonic and postnatal macrophages are necessary for proper tooth development and homeostasis
Gonzalez Lopez M et al. Nat Commun. 2026 Jul 17;17(1):6537. doi: 10.1038/s41467-026-75576-7.
 
20. Identification of the SARS-CoV-2 genome packaging signal in the nsp12-coding region
Park Y et al. Nat Commun. 2026 Jul 10. doi: 10.1038/s41467-026-75008-6. Online ahead of print.
 
21. Mitochondrial translation termination, recycling, reinitiation, and rescue for in-frame and out-of-frame contexts
Wakigawa T et al. Nat Commun. 2026 Jul 21;17(1):6128. doi: 10.1038/s41467-026-75248-6.
 
22. Localized PD-1 CAR T therapy reprograms neuroinflammation
Shalita R et al. Cell. 2026 Jul 21:S0092-8674(26)00756-7. doi: 10.1016/j.cell.2026.06.036. Online ahead of print.
 
23. Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury
Qing J et al. Sci Adv. 2026 Jul 24;12(30):eadw9707. doi: 10.1126/sciadv.adw9707. Epub 2026 Jul 24.
 
24. Single-cell Long-read Transcriptomics: From Technologies to Biological Insights
Ren ZH et al. Gigascience. 2026 Jul 22:giag082. doi: 10.1093/gigascience/giag082. Online ahead of print.
 
25. A map of intra- and intercellular immune responses across diverse in vitro stimuli and inflammatory disease
Wood O et al. Genome Med. 2026 Jul 15. doi: 10.1186/s13073-026-01721-y. Online ahead of print.
 
26. Chromatin end-anchored chromosome-sized domains and promoter loops organize a transcriptionally active genome in Tetrahymena
Hu T et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2607976123. doi: 10.1073/pnas.2607976123. Epub 2026 Jul 16.
 
27. Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition
Wang X et al. Proc Natl Acad Sci U S A. 2026 Jul 28;123(30):e2600323123. doi: 10.1073/pnas.2600323123. Epub 2026 Jul 21.
 
28. PRECISE: A Prognostic Thyrocyte-Derived Gene Signature for Papillary Thyroid Carcinoma
Li S et al. Clin Cancer Res. 2026 Jul 1;32(13):2667-2680. doi: 10.1158/1078-0432.CCR-25-4488.
 
29. Imputing causality and clonal dynamics from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria
Mizumaki H et al. Leukemia. 2026 Jul;40(7):1368-1380. doi: 10.1038/s41375-026-02914-5. Epub 2026 Apr 22.
 
30. Sulfotransferase signaling sustains fibroblast identity and antagonizes therapeutic cardiac reprogramming
Romero MR et al. Nat Commun. 2026 Jul 17. doi: 10.1038/s41467-026-75583-8. Online ahead of print.
 
31. Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia
Radulescu E et al. Nat Commun. 2026 Jul 16. doi: 10.1038/s41467-026-75470-2. Online ahead of print.
 
32. Genetic interrogation reveals mechanisms regulating nexus glia development and shaping heart physiology
Light SEW et al. Dev Cell. 2026 Jul 8;61(7):1555-1571.e7. doi: 10.1016/j.devcel.2026.05.010. Epub 2026 Jun 15.
 
33. Statescope: an integrative deconvolution framework for discovering cell states in tumors
Janssen J et al. Nat Commun. 2026 Jul 6. doi: 10.1038/s41467-026-74997-8. Online ahead of print.
 
34. PTEN acts as a master mediator of nonhealing venous leg ulcers by suppressing immune response, angiogenesis, and lymphangiogenesis
Marjanovic J et al. Sci Transl Med. 2026 Jul 15;18(858):eadv4095. doi: 10.1126/scitranslmed.adv4095. Epub 2026 Jul 15.
 
35. Arginine methyltransferase PRMT1 equipoises trophoblast development to prevent early pregnancy loss
Dasgupta P et al. Nat Commun. 2026 Jul 10. doi: 10.1038/s41467-026-75452-4. Online ahead of print.
 
36. Systematic profiling of AGO2-associated circRNAs and functional investigation reveal circN4BP2L2 as a survival-promoting regulator in T-ALL
Drobna-Sledzinska M et al. Leukemia. 2026 Jul 27. doi: 10.1038/s41375-026-03033-x. Online ahead of print.
 
37. Distinct cell type-specific mechanisms underlie cognitive dysfunction during persistent integrated stress response activation
Torkenczy K et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2537017123. doi: 10.1073/pnas.2537017123. Epub 2026 Jul 14.
 
38. Misregulation of T-box transcription factors drives BNP-NPR1 signalling underlying chronic itch
Dai X et al. Nat Commun. 2026 Jul 17. doi: 10.1038/s41467-026-75726-x. Online ahead of print.
 
39. Forkhead box versus NF-κB hippocampal snRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis
van Loo KMJ et al. J Neuroinflammation. 2026 Jul 7;23(1):232. doi: 10.1186/s12974-026-03951-8.
 
40. WNK2 oncogenicity revealed by the discovery and functional characterization of novel gene isoforms in MYD88 mutated Waldenström's Macroglobulinemia
Guerrera ML et al. Blood Cancer J. 2026 Jul 8. doi: 10.1038/s41408-026-01554-3. Online ahead of print.
 
41. WIP transcriptional regulators modulate developmental progression in both life cycle phases of a moss
Gomez Roldan MV et al. Proc Natl Acad Sci U S A. 2026 Jul 7;123(27):e2603045123. doi: 10.1073/pnas.2603045123. Epub 2026 Jun 29.
 
42. A Phase II Study of Stereotactic Ablative Radiotherapy plus Atezolizumab plus Tiragolumab in Treatment-Naïve Patients with Advanced Non-Small Cell Lung Cancer
Lee JB et al. Clin Cancer Res. 2026 Jul 17;32(14):2898-2910. doi: 10.1158/1078-0432.CCR-25-4990.
 
43. Gene expression-based dissemination score predicts early spread and poor outcomes in multiple myeloma
Bohra A et al. Leukemia. 2026 Jul;40(7):1392-1400. doi: 10.1038/s41375-026-02931-4. Epub 2026 Apr 22.
 
44. Piezo2(+) mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus
Wang Z et al. Gut. 2026 Jul 10:gutjnl-2025-336369. doi: 10.1136/gutjnl-2025-336369. Online ahead of print.
 
45. Single-nucleus analysis of the adult human olfactory epithelium uncovers shared neurogenesis programs with the brain
Song L et al. Nat Commun. 2026 Jul 17. doi: 10.1038/s41467-026-75722-1. Online ahead of print.
 
46. Dosage compensation and meiotic sex chromosome inactivation are maintained under relaxed selection
Parker DJ et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2531501123. doi: 10.1073/pnas.2531501123. Epub 2026 Jul 15.
 
47. Histone chaperone HIRA regulates adiponectin expression and obesity-associated adipose expansion by facilitating Pol II pause release
Wan D et al. Proc Natl Acad Sci U S A. 2026 Jul 14;123(28):e2603875123. doi: 10.1073/pnas.2603875123. Epub 2026 Jul 6.
 
48. Epigenetic signatures mark early peripheral human B lineage bifurcation and differential transcriptional profiles in mature populations
Dionisi C et al. Nat Commun. 2026 Jul 14. doi: 10.1038/s41467-026-75364-3. Online ahead of print.
 
49. CXCL13⁺ CD4⁺ T cells are associated with B-cell recruitment and lesion progression in cerebral cavernous malformations
Zhao S et al. J Neuroinflammation. 2026 Jul 8. doi: 10.1186/s12974-026-03950-9. Online ahead of print.
 
 
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