| Latest Papers(RNA-Seq Part) |
1. SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling
Luo G et al. Science. 2026 Jan;391(6780):eadv6127. doi: 10.1126/science.adv6127. Epub 2026 Jan 1.
2. Advancing Cardiovascular Research With Single-Cell and Spatial Transcriptomics
Li K et al. Circ Res. 2026 Jan 2;138(1):e325795. doi: 10.1161/CIRCRESAHA.125.325795. Epub 2026 Jan 2.
3. Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes
Nan J et al. Nat Metab. 2026 Jan;8(1):139-158. doi: 10.1038/s42255-025-01407-6. Epub 2026 Jan 2.
4. Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma
Chen J et al. Mol Cancer. 2026 Jan 5;25(1):3. doi: 10.1186/s12943-025-02381-z.
5. Molecular and cellular composition changes after neoadjuvant letrozole and palbociclib in early luminal breast cancer
Cottu P et al. Cell Rep Med. 2026 Jan 20;7(1):102544. doi: 10.1016/j.xcrm.2025.102544. Epub 2026 Jan 9.
6. A Stem and Progenitor Cell-Derived Gene Expression Signature is Prognostic for Survival in Myelofibrosis
Medeiros JJF et al. Blood. 2026 Jan 2:blood.2025030094. doi: 10.1182/blood.2025030094. Online ahead of print.
7. RUNX1 N6-methyladenosine methylation enhances cytoskeleton remodeling and boosts cardiac fibrosis
Ding JF et al. Cardiovasc Res. 2026 Jan 20:cvag010. doi: 10.1093/cvr/cvag010. Online ahead of print.
8. Single-cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss
Loft A et al. Nat Metab. 2026 Jan;8(1):260-278. doi: 10.1038/s42255-025-01433-4. Epub 2026 Jan 12.
9. METTL3-mediated m(6)A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca(2+) signaling
Chen C et al. Mol Cancer. 2026 Jan 19. doi: 10.1186/s12943-025-02553-x. Online ahead of print.
10. Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution
Hendriksen JD et al. Genome Biol. 2026 Jan 29;27(1):10. doi: 10.1186/s13059-026-03933-2.
11. Establishing the relationship between brain cellular senescence and brain structure
Lund AN et al. Cell. 2026 Jan 22;189(2):511-527.e17. doi: 10.1016/j.cell.2025.10.014.
12. PU.1-Activated Genomic Regions Define Low-risk MDS Subsets Characterized by Immune Dysregulation and Disease Progression
Vallelonga V et al. Blood. 2026 Jan 15:blood.2025030760. doi: 10.1182/blood.2025030760. Online ahead of print.
13. Non-negative matrix factorization and deconvolution as a dual simplex problem
Kleverov D et al. Genome Biol. 2026 Jan 14. doi: 10.1186/s13059-025-03910-1. Online ahead of print.
14. Transcriptomic signature-guided depletion of intermediate alveolar epithelial cells ameliorates pulmonary fibrosis in mice
Peng F et al. Nat Commun. 2026 Jan 10. doi: 10.1038/s41467-026-68354-y. Online ahead of print.
15. Cognitive dysfunction in type 1 diabetes: role of TREM2 in microglial activation and Aβ pathology
Wang Y et al. J Neuroinflammation. 2026 Jan 2;23(1):15. doi: 10.1186/s12974-025-03611-3.
16. Safety, feasibility and pharmacodynamic activity of intratumoral injections of the agonist anti-CD137 (4-1BB) mAb urelumab in combination with nivolumab
Sanmamed MF et al. Clin Cancer Res. 2026 Jan 16. doi: 10.1158/1078-0432.CCR-25-2502. Online ahead of print.
17. Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics
Dong Y et al. Genome Biol. 2026 Jan 2;27(1):11. doi: 10.1186/s13059-025-03917-8.
18. MER57E3 transposable elements regulate gene expression in a human cell model of neural development
Almeida da Paz M et al. Genome Biol. 2026 Jan 31. doi: 10.1186/s13059-026-03946-x. Online ahead of print.
19. Global atlas of enhancer-promoter interactome in cotton genome revealed by profiling RNA-RNA spatial interactions
Wen M et al. Genome Biol. 2026 Jan 2;27(1):12. doi: 10.1186/s13059-025-03907-w.
20. SAMSN1 restrains NK cell mediated anti-tumor immunity in hepatocellular carcinoma
Wang R et al. Nat Commun. 2026 Jan 21. doi: 10.1038/s41467-026-68661-4. Online ahead of print.
21. Validation of a seven-gene predictive SIGNature for the efficacy of Immuno-Oncology PD-1 inhibitors in patients with Sarcoma (SIGNIOS)
Moura DS et al. Clin Cancer Res. 2026 Jan 15. doi: 10.1158/1078-0432.CCR-25-2580. Online ahead of print.
22. omnideconv: a unifying framework for using and benchmarking single-cell-informed deconvolution of bulk RNA-seq data
Dietrich A et al. Genome Biol. 2026 Jan 26;27(1):6. doi: 10.1186/s13059-026-03955-w.
23. Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy
Zeng W et al. Cell Rep Med. 2026 Jan 20;7(1):102528. doi: 10.1016/j.xcrm.2025.102528. Epub 2026 Jan 5.
24. Leveraging Low-Cost Short-Read Sequencing: Revolutionizing Complex Trait Genetics
Ruckman SN et al. Mol Biol Evol. 2026 Jan 28:msag025. doi: 10.1093/molbev/msag025. Online ahead of print.
25. Distinct T and innate-like lymphocyte reprogramming following lyophilized fecal microbiota transplantation in recurrent C. difficile infection
Gao Y et al. Gut Microbes. 2026 Dec 31;18(1):2620127. doi: 10.1080/19490976.2026.2620127. Epub 2026 Jan 23.
26. Biochemical principles of miRNA targeting in flies
Vega-Badillo J et al. Nat Commun. 2026 Jan 20. doi: 10.1038/s41467-026-68360-0. Online ahead of print.
27. Evaluating deconvolution methods using real bulk RNA-expression data for robust prognostic insights across cancer types
Li M et al. Genome Biol. 2026 Jan 21. doi: 10.1186/s13059-026-03942-1. Online ahead of print.
28. Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility
Chen Z et al. Nat Commun. 2026 Jan 15. doi: 10.1038/s41467-025-68127-z. Online ahead of print.
29. Exploratory Analysis of Biomarkers and Treatment Outcomes From the COLUMBUS Study in BRAF V600E/K-Mutant Advanced or Metastatic Melanoma
Dummer R et al. Clin Cancer Res. 2026 Jan 15. doi: 10.1158/1078-0432.CCR-25-3262. Online ahead of print.
30. Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML
Huang Y et al. Cell Rep Med. 2026 Jan 20;7(1):102542. doi: 10.1016/j.xcrm.2025.102542.
31. SCITO-seq2: ultra-high-throughput single-cell transcriptome and epitope sequencing
Lee SH et al. Genome Biol. 2026 Jan 27. doi: 10.1186/s13059-026-03954-x. Online ahead of print.
32. Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas
Viswanathan G et al. Sci Adv. 2026 Jan 23;12(4):eadw4619. doi: 10.1126/sciadv.adw4619. Epub 2026 Jan 21.
33. A triple-node heart-brain neuroimmune loop underlying myocardial infarction
Yadav S et al. Cell. 2026 Jan 27:S0092-8674(25)01506-5. doi: 10.1016/j.cell.2025.12.058. Online ahead of print.
34. TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data
Herrmann M et al. Genome Biol. 2026 Jan 19;27(1):5. doi: 10.1186/s13059-026-03941-2.
35. A bacterial translation activator with an intrinsically disordered RNA-binding region
Basu P et al. Proc Natl Acad Sci U S A. 2026 Jan 20;123(3):e2519770123. doi: 10.1073/pnas.2519770123. Epub 2026 Jan 16.
36. VIST: variational inference for single cell time series
Xu B et al. Genome Biol. 2026 Jan 15. doi: 10.1186/s13059-025-03874-2. Online ahead of print.
37. Parameter-efficient fine-tuning enables scalable transfer of regulatory sequence models to novel contexts
Yuan H et al. Genome Biol. 2026 Jan 30. doi: 10.1186/s13059-026-03935-0. Online ahead of print.
38. Unveiling the early defense response dynamics in grapevines against Plasmopara viticola by single-cell transcriptomics
Yao X et al. Genome Biol. 2026 Jan 27. doi: 10.1186/s13059-025-03904-z. Online ahead of print.
39. Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection
Pfefferkorn AM et al. Nat Commun. 2026 Jan 28;17(1):1060. doi: 10.1038/s41467-026-68397-1.
40. Genomic language model mitigates chimera artifacts in nanopore direct RNA sequencing
Li Y et al. Nat Commun. 2026 Jan 19. doi: 10.1038/s41467-026-68571-5. Online ahead of print.
41. Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer
Chang YH et al. Gut. 2026 Jan 30:gutjnl-2025-337247. doi: 10.1136/gutjnl-2025-337247. Online ahead of print.
42. Systemic immune correlates of long-term survival after Delta-24-RGD based on the Therapeutic Adenovirus for Recurrent Glioblastoma Effect Trial (TARGET)
Ene CI et al. Clin Cancer Res. 2026 Jan 29. doi: 10.1158/1078-0432.CCR-25-3566. Online ahead of print.
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