| Latest Papers(RNA-Seq Part) |
1. A multi-agent system for automating scientific discovery
Ghareeb AE et al. Nature. 2026 May 19. doi: 10.1038/s41586-026-10652-y. Online ahead of print.
2. Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts
Merkt W et al. Sci Transl Med. 2026 May 13;18(849):eadq5442. doi: 10.1126/scitranslmed.adq5442. Epub 2026 May 13.
3. Sensory nerves protect against preclinical tendinopathic changes through FGF1 signaling
Zhu M et al. Sci Transl Med. 2026 May 13;18(849):eaec1380. doi: 10.1126/scitranslmed.aec1380. Epub 2026 May 13.
4. A stem and progenitor cell-derived gene expression signature is prognostic for survival in myelofibrosis
Medeiros JJF et al. Blood. 2026 May 7;147(19):2238-2251. doi: 10.1182/blood.2025030094.
5. RegVelo: Gene-regulatory-informed dynamics of single cells
Wang W et al. Cell. 2026 May 11:S0092-8674(26)00457-5. doi: 10.1016/j.cell.2026.04.022. Online ahead of print.
6. ERG is a regulator of dynamic and reversible endothelial plasticity
Schulz K et al. Genome Med. 2026 May 1;18(1):53. doi: 10.1186/s13073-026-01638-6.
7. Association of Circulating T Cell and Tumor Microenvironment Profiles with Immune Checkpoint Blockade Outcomes in Sarcoma
Rosenbaum E et al. Clin Cancer Res. 2026 May 1;32(9):1777-1789. doi: 10.1158/1078-0432.CCR-25-3419.
8. Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer
Wu YC et al. Nat Immunol. 2026 May 12. doi: 10.1038/s41590-026-02515-5. Online ahead of print.
9. Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies
Chen LY et al. Blood. 2026 May 8:blood.2025030891. doi: 10.1182/blood.2025030891. Online ahead of print.
10. OptoRibo-seq for spatiotemporally resolved mapping of the local protein translatome
Wang R et al. Proc Natl Acad Sci U S A. 2026 May 26;123(21):e2519235123. doi: 10.1073/pnas.2519235123. Epub 2026 May 20.
11. scSurvival: Single-Cell Survival Analysis of Clinical Cancer Cohort Data at Cellular Resolution
Ren T et al. Cancer Discov. 2026 May 1;16(5):931-952. doi: 10.1158/2159-8290.CD-25-0965.
12. N6-methyladenosine reader IGF2BP2 in T-cell lymphoma
Hu S et al. Blood. 2026 May 21:blood.2026034186. doi: 10.1182/blood.2026034186. Online ahead of print.
13. A single-cell atlas revealing cellular heterogeneity across healthy and diseased human thymus
Direder M et al. Nat Commun. 2026 May 6. doi: 10.1038/s41467-026-72760-7. Online ahead of print.
14. Regulatory-like FOXP3+Helios+CD4+ T conventional cells correlate with T-cell activation after Orca-T immunotherapy
Bader CS et al. Blood. 2026 May 21;147(21):2489-2502. doi: 10.1182/blood.2025031545.
15. VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes
Han X et al. Signal Transduct Target Ther. 2026 May 18;11(1):185. doi: 10.1038/s41392-026-02701-9.
16. RNA splicing in human cardiomyopathies: shared landscape in diverse pathogenic paths
Wang Y et al. Cardiovasc Res. 2026 May 22;122(7):808-809. doi: 10.1093/cvr/cvag070.
17. Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2
Zhu C et al. Cardiovasc Res. 2026 May 22;122(7):892-905. doi: 10.1093/cvr/cvag066.
18. Single-Cell RNA-seq Analysis Reveals Distinct Tumor and Immunosuppressive T-Cell Phenotypes in Patients with CLL Treated with Ibrutinib
Thangavadivel S et al. Clin Cancer Res. 2026 May 1;32(9):1874-1886. doi: 10.1158/1078-0432.CCR-25-3349.
19. Developmental landmarks and cellular transitions during extravillous trophoblast cell differentiation
Moreno-Irusta A et al. Proc Natl Acad Sci U S A. 2026 May 12;123(19):e2529836123. doi: 10.1073/pnas.2529836123. Epub 2026 May 6.
20. Alternative polyadenylation dynamics shape pollen development at single-cell resolution
Zhao Z et al. Plant Cell. 2026 May 5;38(5):koag128. doi: 10.1093/plcell/koag128.
21. HHIP's dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility
Deritei D et al. Proc Natl Acad Sci U S A. 2026 Jun 2;123(22):e2424377123. doi: 10.1073/pnas.2424377123. Epub 2026 May 26.
22. SCOTCH: isoform-level characterization of gene expression through long-read single-cell RNA sequencing
Xu Z et al. Nat Commun. 2026 May 7. doi: 10.1038/s41467-026-72665-5. Online ahead of print.
23. High-fidelity genome and prime editing enabled by the AI-designed openCRISPR-1
Hwang HY et al. Genome Med. 2026 May 26. doi: 10.1186/s13073-026-01682-2. Online ahead of print.
24. Spatiotemporal analysis reveals distinct inflammatory programs underlying chronic colitis
Fransson J et al. Immunity. 2026 May 6:S1074-7613(26)00167-6. doi: 10.1016/j.immuni.2026.04.005. Online ahead of print.
25. Single-cell and spatial omics in liver identify cell-cell communication regulators in aging and insulin resistance
Zhao W et al. Metabolism. 2026 May 9;181:156630. doi: 10.1016/j.metabol.2026.156630. Online ahead of print.
26. Efficacy of the ATR Inhibitor Ceralasertib in Patients with ARID1A-Deficient Gynecologic and Other Solid Tumor Malignancies
Zhu X et al. Clin Cancer Res. 2026 May 1;32(9):1632-1640. doi: 10.1158/1078-0432.CCR-25-4043.
27. Dissecting reversible and irreversible single cell state transitions from gene regulatory networks
Ramirez DA et al. Mol Syst Biol. 2026 May;22(5):811-832. doi: 10.1038/s44320-026-00196-8. Epub 2026 Feb 9.
28. The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation
Piscitelli S et al. Cell Death Differ. 2026 May 5. doi: 10.1038/s41418-026-01753-2. Online ahead of print.
29. A CSF disease-associated macrophage signature defines progressive multiple sclerosis
Börsch AL et al. J Neuroinflammation. 2026 May 13;23(1):156. doi: 10.1186/s12974-026-03861-9.
30. Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis
Azmain T et al. Cardiovasc Res. 2026 May 22;122(7):919-934. doi: 10.1093/cvr/cvag050.
31. Chromatin rewiring of β-globin and MYC enhancers by TGF-β1 drives defective erythropoiesis
Aluri S et al. Nat Commun. 2026 May 13. doi: 10.1038/s41467-026-72963-y. Online ahead of print.
32. RNA-seq sheds light on "who is doing what" in the coral Porites lutea
Tandon K et al. Microbiome. 2026 May 2. doi: 10.1186/s40168-026-02414-9. Online ahead of print.
33. Preemptive cardioprotection with a small molecule in rodents that suppresses genes predictive of heart failure
Li Y et al. Sci Adv. 2026 May 15;12(20):eaea0220. doi: 10.1126/sciadv.aea0220. Epub 2026 May 13.
34. Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma
Wu Y et al. Genome Med. 2026 May 6. doi: 10.1186/s13073-026-01663-5. Online ahead of print.
35. Eosinophil-derived COX-2 protects against experimental colitis through the PGE(2)-IL-22 axis
Yang Y et al. Proc Natl Acad Sci U S A. 2026 May 12;123(19):e2525334123. doi: 10.1073/pnas.2525334123. Epub 2026 May 4.
36. scArchon: a scalable benchmarking framework for assessing single-cell perturbation models
Radig J et al. Genome Biol. 2026 May 12;27(1):162. doi: 10.1186/s13059-026-04104-z.
37. Spatiotemporal regulation of arbuscular mycorrhizal symbiosis at cellular resolution
Chancellor T et al. Plant Cell. 2026 May 11:koag133. doi: 10.1093/plcell/koag133. Online ahead of print.
38. FIRST-seq: a nanopore-based cDNA sequencing platform for RNA modification and structure profiling
Begik O et al. Genome Biol. 2026 May 30. doi: 10.1186/s13059-026-04115-w. Online ahead of print.
39. SIRT6 overexpression counteracts chromatin aging in the male murine liver
Nagar R et al. Nat Commun. 2026 May 14. doi: 10.1038/s41467-026-73115-y. Online ahead of print.
40. Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta
Kast R et al. Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2509781123. doi: 10.1073/pnas.2509781123. Epub 2026 Apr 29.
41. TAZ integrates ECM remodeling with uterine stromal differentiation to maintain early pregnancy
He X et al. Proc Natl Acad Sci U S A. 2026 May 26;123(21):e2528309123. doi: 10.1073/pnas.2528309123. Epub 2026 May 19.
42. Unleashing the potential of mRNA-seq to uncover the microbiome structure and their crosstalk with host cells: the vulvar ecosystem
Monteleone E et al. Microbiome. 2026 May 7;14(1):138. doi: 10.1186/s40168-026-02420-x.
43. A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity
Xia M et al. Dev Cell. 2026 May 11:S1534-5807(26)00152-8. doi: 10.1016/j.devcel.2026.04.005. Online ahead of print.
44. Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma
Wylie D et al. Sci Adv. 2026 May;12(18):eadu0031. doi: 10.1126/sciadv.adu0031. Epub 2026 May 1.
45. 10 × Genomics Flex Gene Expression is a powerful tool for single-cell transcriptomics of xenografts models
Llorà-Batlle O et al. Genome Biol. 2026 May 8. doi: 10.1186/s13059-026-04092-0. Online ahead of print.
46. CLASHub is an integrated database and analytical platform for microRNA-target interactions
Li L et al. Nat Commun. 2026 May 8. doi: 10.1038/s41467-026-72902-x. Online ahead of print.
47. Translational evidence for increased central amygdala IL-6 activity in alcohol dependence
St Onge CM et al. J Neuroinflammation. 2026 May 22. doi: 10.1186/s12974-026-03868-2. Online ahead of print.
48. Serum Response Factor (SRF) promotes actin cytoskeletal organization in adipocytes to support adaptive hypertrophic expansion and tissue remodeling during obesity in mice
So J et al. Metabolism. 2026 May;178:156548. doi: 10.1016/j.metabol.2026.156548. Epub 2026 Feb 6.
49. DeepSAP: improved RNA-seq alignment by integrating transcriptome guidance with transformer-based splice junction scoring
Berakdar F et al. Genome Biol. 2026 May 9. doi: 10.1186/s13059-026-04100-3. Online ahead of print.
50. Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study
Dantas E et al. Nat Commun. 2026 May 27. doi: 10.1038/s41467-026-73519-w. Online ahead of print.
51. Distinct activity in prefrontal projections promotes temporal control of action
Ding X et al. Proc Natl Acad Sci U S A. 2026 May 12;123(19):e2538059123. doi: 10.1073/pnas.2538059123. Epub 2026 May 6.
52. Circulating extracellular vesicle long RNA profiling combined with machine learning unveils novel diagnostic signature and molecular features in chronic pancreatitis
Cao Y et al. Gut. 2026 May 8:gutjnl-2025-335957. doi: 10.1136/gutjnl-2025-335957. Online ahead of print.
53. Vacuolar iron transporters mediate resistance to triadimefon in plant pathogenic fungi
Ji F et al. Nat Commun. 2026 May 6. doi: 10.1038/s41467-026-72157-6. Online ahead of print.
54. D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response
Jiang J et al. Cell. 2026 May 12:S0092-8674(26)00463-0. doi: 10.1016/j.cell.2026.04.028. Online ahead of print.
55. Data-driven AI system for learning how to run transcript assemblers
Shen Y et al. Genome Biol. 2026 May 12. doi: 10.1186/s13059-026-04085-z. Online ahead of print.
56. Macrophage-derived SPP1 promotes subretinal fibrosis by YAP1 phase separation in retinal pigment epithelium
Lin R et al. Metabolism. 2026 May 19;181:156648. doi: 10.1016/j.metabol.2026.156648. Online ahead of print.
57. CD38⁺ endothelial remodeling marks spatially patterned vasculopathy in rapidly advancing periodontitis and peri-implantitis
Easter QT et al. Nat Commun. 2026 May 8. doi: 10.1038/s41467-026-72452-2. Online ahead of print.
58. RVG-Modified BMSCs-Derived Small Extracellular Vesicles Loaded With miR-21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia
Li Y et al. J Extracell Vesicles. 2026 May;15(5):e70295. doi: 10.1002/jev2.70295.
59. PAX4 R192H variant impairs β cell function by disrupting β cell identity and compensatory capacity in response to metabolic stress
Park J et al. Genome Med. 2026 May 28. doi: 10.1186/s13073-026-01669-z. Online ahead of print.
60. Transcriptomic Subgroups in Soft Tissue Tumors Correlate with Morphologic Subtype, Genomic Features, and Outcome
Hofvander J et al. Clin Cancer Res. 2026 May 1;32(9):1825-1834. doi: 10.1158/1078-0432.CCR-25-3740.
61. R-loop homeostasis at transposable elements safeguards transcriptional silencing in replication-quiescent oocytes
Liu SY et al. Nat Commun. 2026 May 29. doi: 10.1038/s41467-026-73781-y. Online ahead of print.
62. FaNUDT19 contributes to 5' cap quality control by modulating NAD+ capped RNA dynamics during strawberry fruit ripening
Ma Q et al. Plant Cell. 2026 May 5;38(5):koag102. doi: 10.1093/plcell/koag102.
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