| Latest Papers(RNA-Seq Part) |
1. RegVelo: Gene-regulatory-informed dynamics of single cells
Wang W et al. Cell. 2026 Jun 11;189(12):3773-3800.e44. doi: 10.1016/j.cell.2026.04.022. Epub 2026 May 12.
2. A Tumor-Promoting Inflammatory SPP1+ Macrophage-IL6-CRP Axis Drives Immune Dysfunction in Bladder Cancer
Tran MA et al. Cancer Discov. 2026 Jun 1;16(6):1126-1151. doi: 10.1158/2159-8290.CD-25-1774.
3. Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer
Wu YC et al. Nat Immunol. 2026 Jun;27(6):1268-1281. doi: 10.1038/s41590-026-02515-5. Epub 2026 May 12.
4. A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer
Caire R et al. Cell. 2026 Jun 11;189(12):3701-3718.e30. doi: 10.1016/j.cell.2026.03.009. Epub 2026 Mar 31.
5. SPP1(+) macrophages facilitate the differentiation and maturation of regulatory T cells in tumour-draining lymph nodes of colorectal cancer
Wang J et al. Gut. 2026 Jun 12:gutjnl-2025-337038. doi: 10.1136/gutjnl-2025-337038. Online ahead of print.
6. Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma
Ghannam JY et al. Nat Cancer. 2026 Jun;7(6):964-982. doi: 10.1038/s43018-026-01179-2. Epub 2026 Jun 3.
7. A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution
Ye H et al. Cancer Discov. 2026 Jun 8. doi: 10.1158/2159-8290.CD-25-0964. Online ahead of print.
8. eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation
Kunitomi H et al. Cell Stem Cell. 2026 Jun 4;33(6):1000-1015.e11. doi: 10.1016/j.stem.2026.04.006. Epub 2026 Apr 30.
9. An emergent disease-associated motor neuron state precedes cell death in ALS
Gautier O et al. Cell. 2026 Jun 23:S0092-8674(26)00647-1. doi: 10.1016/j.cell.2026.05.047. Online ahead of print.
10. Spatiotemporal analysis reveals distinct inflammatory programs underlying chronic colitis
Fransson J et al. Immunity. 2026 Jun 9;59(6):1599-1615.e5. doi: 10.1016/j.immuni.2026.04.005. Epub 2026 May 6.
11. Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis
Krzak M et al. Nat Genet. 2026 Jun 15. doi: 10.1038/s41588-026-02634-7. Online ahead of print.
12. Targeted Delivery of mRNA to the Heart via Extracellular Vesicles or Lipid Nanoparticles
Nawaz M et al. J Extracell Vesicles. 2026 Jun;15(6):e70324. doi: 10.1002/jev2.70324.
13. Mapping cell type-resolved transcriptomic profiles to patient survival in pancreatic cancer
Tang R et al. Cancer Cell. 2026 Jun 11:S1535-6108(26)00257-6. doi: 10.1016/j.ccell.2026.05.012. Online ahead of print.
14. Study of NSD2 using a dTAG system reveals its molecular mechanism and oncogenic implications in t(4;14) multiple myeloma
Wang Y et al. Blood. 2026 Jun 11;147(24):2916-2929. doi: 10.1182/blood.2025031663.
15. Continuous modeling of primate embryogenesis from totipotency to early organogenesis
Zheng W et al. Cell. 2026 Jun 10:S0092-8674(26)00582-9. doi: 10.1016/j.cell.2026.05.023. Online ahead of print.
16. PKMYT1 is a Targetable Vulnerability in del(17p) High-Risk Multiple Myeloma
Schavgoulidze A et al. Blood. 2026 Jun 3:blood.2026033819. doi: 10.1182/blood.2026033819. Online ahead of print.
17. A 3'UTR-derived small RNA modulates the life cycle of the cholera toxin-encoding filamentous phage, CTXϕ
Lippegaus A et al. Proc Natl Acad Sci U S A. 2026 Jun 9;123(23):e2535142123. doi: 10.1073/pnas.2535142123. Epub 2026 Jun 2.
18. Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models
Nehme Z et al. Sci Transl Med. 2026 Jun 3;18(852):eadp2595. doi: 10.1126/scitranslmed.adp2595. Epub 2026 Jun 3.
19. Spatiotemporal regulation of arbuscular mycorrhizal symbiosis at cellular resolution
Chancellor T et al. Plant Cell. 2026 Jun 2;38(6):koag133. doi: 10.1093/plcell/koag133.
20. GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain
Liu M et al. Proc Natl Acad Sci U S A. 2026 Jun 9;123(23):e2610646123. doi: 10.1073/pnas.2610646123. Epub 2026 Jun 1.
21. Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis
Goto S et al. Cell Stem Cell. 2026 Jun 22:S1934-5909(26)00205-5. doi: 10.1016/j.stem.2026.05.013. Online ahead of print.
22. Active-learning-guided optimization of cell-free systems for genome-wide transcriptomic profiling reveals progressive layers of regulation
Wagner L et al. Nat Commun. 2026 Jun 27. doi: 10.1038/s41467-026-74559-y. Online ahead of print.
23. Compound models and Pearson residuals for single-cell RNA-seq data without UMIs
Lause J et al. Genome Biol. 2026 Jun 27. doi: 10.1186/s13059-026-04161-4. Online ahead of print.
24. GREM1/FGFR1-activated myofibroblasts induce immunosuppression and accelerate metastasis in high-grade serous ovarian cancer
Li R et al. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2529786123. doi: 10.1073/pnas.2529786123. Epub 2026 Jun 10.
25. Histaminylation alters collagen matrix mechanics and attenuates cardiac fibrosis post-myocardial infarction via mechanotransduction signaling axis
Zhu J et al. Signal Transduct Target Ther. 2026 Jun 11;11(1):229. doi: 10.1038/s41392-026-02721-5.
26. A cytoplasmic index for quantifying immune-related A-to-I RNA editing
Cohen-Fultheim R et al. Genome Biol. 2026 Jun 17. doi: 10.1186/s13059-026-04154-3. Online ahead of print.
27. D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response
Jiang J et al. Cell. 2026 Jun 25;189(13):4159-4184.e35. doi: 10.1016/j.cell.2026.04.028. Epub 2026 May 12.
28. Integrated Single-Cell and Spatial Analysis Reveals Context-Dependent Myeloid-T Cell Interactions in Response to Immune Checkpoint Blockade in Head and Neck Cancer
Golfinos-Owens AE et al. Clin Cancer Res. 2026 Jun 15;32(12):2494-2507. doi: 10.1158/1078-0432.CCR-25-2300.
29. A tunable Cas12a platform for single-cell perturbation screening and CRISPRi
Snetkova V et al. Nat Commun. 2026 Jun 2. doi: 10.1038/s41467-026-73955-8. Online ahead of print.
30. TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells
Wang Y et al. Nat Cell Biol. 2026 Jun 11. doi: 10.1038/s41556-026-01985-x. Online ahead of print.
31. SREBP2 links ACSS2-dependent acetyl-CoA biosynthesis to metaboloepigenetic activation of hepatic stellate cells and liver fibrosis
Wang Y et al. Metabolism. 2026 Jun;179:156597. doi: 10.1016/j.metabol.2026.156597. Epub 2026 Mar 24.
32. Dynamic cell fate transitions during morphallactic regeneration
Nuninger C et al. Nat Commun. 2026 Jun 2. doi: 10.1038/s41467-026-73887-3. Online ahead of print.
33. circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics
Plumbom I et al. Genome Med. 2026 Jun 10;18(1):84. doi: 10.1186/s13073-026-01691-1.
34. Spatial and single-cell transcriptomics uncover brassinosteroid-mediated coordination of sepal elongation in Arabidopsis
Rusnak B et al. Genome Biol. 2026 Jun 17. doi: 10.1186/s13059-026-04156-1. Online ahead of print.
35. Interpretable multi-omics integration across mixed-order tensors with MANTRA
De Azevedo K et al. Mol Syst Biol. 2026 Jun 18. doi: 10.1038/s44320-026-00223-8. Online ahead of print.
36. Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes
Whitney ON et al. Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2605749123. doi: 10.1073/pnas.2605749123. Epub 2026 Jun 16.
37. ESR1 mutations and CDK4/6 inhibitor choice shape clonal selection and adaptive cell states during acquired resistance
Guarducci C et al. Genome Med. 2026 Jun 27. doi: 10.1186/s13073-026-01690-2. Online ahead of print.
38. Galectin-1 Fuels Monocyte Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms
He F et al. Blood. 2026 Jun 23:blood.2025032631. doi: 10.1182/blood.2025032631. Online ahead of print.
39. HHIP's dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility
Deritei D et al. Proc Natl Acad Sci U S A. 2026 Jun 2;123(22):e2424377123. doi: 10.1073/pnas.2424377123. Epub 2026 May 26.
40. Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance
Li 李怡灵 Y et al. Sci Adv. 2026 Jun 26;12(26):eaea9974. doi: 10.1126/sciadv.aea9974. Epub 2026 Jun 26.
41. A simple cell-cycle control system in Marchantia polymorpha provides a framework for understanding plant cell proliferation
Romani F et al. Plant Cell. 2026 Jun 2;38(6):koag103. doi: 10.1093/plcell/koag103.
42. Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism
Stupakov P et al. Gut. 2026 Jun 23:gutjnl-2025-337316. doi: 10.1136/gutjnl-2025-337316. Online ahead of print.
43. A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity
Xia M et al. Dev Cell. 2026 Jun 10;61(6):1319-1339.e8. doi: 10.1016/j.devcel.2026.04.005. Epub 2026 May 11.
44. Wounding activates the HSFA1 transcription factors to promote cellular reprogramming in Arabidopsis
Coleman D et al. Plant Cell. 2026 Jun 2;38(6):koag124. doi: 10.1093/plcell/koag124.
45. Genetic interrogation reveals mechanisms regulating nexus glia development and shaping heart physiology
Light SEW et al. Dev Cell. 2026 Jun 15:S1534-5807(26)00194-2. doi: 10.1016/j.devcel.2026.05.010. Online ahead of print.
46. Benchmarking Q40 sequencing for sensitive and efficient detection of rare genomic variants
Duan S et al. Genome Biol. 2026 Jun 12. doi: 10.1186/s13059-026-04146-3. Online ahead of print.
47. ChatMDV: Reducing Technical Barriers in Bioinformatics Analysis using Large Language Models
Kiourlappou M et al. Gigascience. 2026 Jun 19:giag073. doi: 10.1093/gigascience/giag073. Online ahead of print.
48. WIP transcriptional regulators modulate developmental progression in both life cycle phases of a moss
Gomez Roldan MV et al. Proc Natl Acad Sci U S A. 2026 Jul 7;123(27):e2603045123. doi: 10.1073/pnas.2603045123. Epub 2026 Jun 29.
49. Diminished transcriptional activity and splicing changes drive gene length-biased rewiring in the aging transcriptome
Parast S et al. Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2607264123. doi: 10.1073/pnas.2607264123. Epub 2026 Jun 16.
50. Gene expression profiles of carotid plaques differ between patients with amaurosis fugax and those with cerebral transient ischemic attack or stroke
Lan T et al. Cardiovasc Res. 2026 Jun 2:cvag116. doi: 10.1093/cvr/cvag116. Online ahead of print.
51. Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME
Singh A et al. Mol Syst Biol. 2026 Jun;22(6):928-961. doi: 10.1038/s44320-026-00201-0. Epub 2026 Mar 10.
52. Ionizing Radiation Enhances Prognostically Significant Cellular Immunity Programs in the Brain Metastasis Microenvironment
Fukumura K et al. Clin Cancer Res. 2026 Jun 1;32(11):2305-2316. doi: 10.1158/1078-0432.CCR-25-3525.
53. OTTR-seq profiling reveals dynamic tRNA modification landscapes across diverse archaeal species
Leavitt JS et al. Genome Biol. 2026 Jun 18. doi: 10.1186/s13059-026-04158-z. Online ahead of print.
54. Srr2-dependent SOX2 levels govern the chromatin and transcriptional landscape of adult neural stem cell fate decisions in mouse
Cruces-Salguero S et al. Genome Biol. 2026 Jun 25;27(1):208. doi: 10.1186/s13059-026-04126-7.
55. PRP8 regulates chromatin organization to enforce transcriptional gene silencing independent of DNA methylation
Qi L et al. Plant Cell. 2026 Jun 8:koag167. doi: 10.1093/plcell/koag167. Online ahead of print.
56. Regulatory logic underlying neural crest contributions to the head versus the heart
Gandhi S et al. Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2512031123. doi: 10.1073/pnas.2512031123. Epub 2026 Jun 15.
57. CCL3+ Neutrophil Signature Predicts Response to Neoadjuvant Toripalimab plus Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Phase II Trial
Chen F et al. Clin Cancer Res. 2026 Jun 1;32(11):2166-2182. doi: 10.1158/1078-0432.CCR-25-4096.
58. Infiltrating monocyte-derived macrophages does not survive long term in stroke brain despite their dominance in the acute ischemic core and myeloid derived IGF-1 play dichotomous roles in stroke recovery
Ma H et al. Genome Med. 2026 Jun 10. doi: 10.1186/s13073-026-01687-x. Online ahead of print.
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