Lab. Automation & Microarrayer

The ACSIA Line from Primadiag(www.primadiag.com), is the innovative automation solution bringing quality, cost efficiency and simplicity to all the genomics (specifically NGS) and proteomics laboratories. The ACSIA product line is designed as the best value for money to perform a wide variety of liquid handling protocols with the lowest effort from the end user. It offers a mastered cost for a fast return on investment.

The ACSIA Line from PrimaDiag, ACSIA is the largest of our platforms. With 16 SBS positions, it allows to perform complex protocols by adding numerous modules to its workspace like shakers, thermoregulated modules or magnetic work units. ACSIA XS is the most compact of our platforms with 8 SBS positions and its 3 XS racks for tubes. It can integrate one 1- or one 8- channels pipette to process a wide variety of protocols of liquid handling.

	ACSIA	ACSIA XS
Size LxDxH	100x72x75cm	78x72x75cm
No of Position for SBS plate or others	16 Positions	8 Positions
Main Application	High efficient PCR/qPCR High efficient Clean-up NGS library NGS target enrichment	Compact PCR/qPCR Compact Clean-up
Custom Protocol	>Yes	>Yes
Software	PrimaControllerII	PrimaControllerII

For each of your need, PrimaDiag intends to respond by tuning your configuration in four steps:
1. Analyze and define the application
2. Choose the adapted platform
3. Determine and integrate the suitable accessories
4. Write and optimize your protocols on your specific configuration

Application(Needs)	ACSIA PCR Edition	ACSIA Clean-up Edition	ACSIA NGS Edition
General pipetting tasks
Distribution	V	V	V
Tube to plate transfer	V	V	V
Plate to plate transfer	V	V	V
Serial dilutions	V	V	V
Hit picking	V	V	V
Concentration normalization	V	V	V
Plate compression/decompression	V	V	V
Genomics
PCR Setup in 96 and 384-well plate	V	V	V
Real ime PCR Setup in 96 and 384-well plate	V	V	V
SNP detection	V	V	V
HLA genotyping	V	V	V
Forensics		V	V
Sequencing setup		V	V
Nucleic Acid purification
PCR and sequencing clean-up		V	V
gDNA from various matrixes		V	V
Plasmid preparation		V	V
Next Generation Sequencing
Library preparation for NGS			V
Enrichment for NGS			V
Proteins
Sample preparation for LC-MS/MS analysis		V	V
Cloning & Synthetic biology
Gibson Assembly cloning			V

BioSpo^t® Worksations from Biofluidix(www.biofluidix.com) are the perfect automation platform for your dispensing applications based on our single channel and microarray products and can be equipped to your needs with up to 12 dispensing channels as well as optical process control features.

The BioSpot BT is by default equipped with our TopView and SmartDrop process control features. So, you don’t even have to manually set the dispensing parameters for your PipeJet NanoDispenser channels. The BioSpot BT will do that automatically for you. You only have to set your single droplet target volume in the software. With the TopView camera you can control the dispensing performance after processing your substrate. The pictures taken are stored and you can use them for internal process documentation and quality control.

	BioSpot BT 600	BioSpot BT 750
Compatible Dispensers	SiJet PicoDispenser PipeJet NanoDispenser ValveJet MicroDispenser	SiJet PicoDispenser PipeJet NanoDispenser ValveJet MicroDispenser
Max. number of dispensing channels	12 channels	12 channels
Asipration possible	Yes	Yes
Max. number of aspiration channelsl	>8 channels	>8 channels
Max. addressable area | mm	300 x 400	300 x 550
Dimensions | cm (H x W x D)	54 x 55 x 63	54 x 55 x 78
Integrated SmartDrop TopView Camera	Yes	Yes
Ingerated Electronics	Control ElectroniX 200	Control ElectroniX 200

• Inbuilt process control systems | SmartDrop & TopView Camera
• Automated single droplet volume calibration
• Dynamic volume range from picoliter to microliter
• Compatible to almost every substrate

• Automated volume calibration available for BT line
• Works in the picoliter, nanoliter and microliter range
• Provides optical process control
• BioSpot Custom can be designed to your specific needs
• Low maintenance costs
• Ideal for decentralized use

Life Science	Industry
Printing of Lateral Flow Assays	Coating of medical products
Printing of microarrays	Printing of adhesives
Filling of microfluidic chips	Flux dispensing
Miniaturization of assays	Surface optimization

OptiSpot^TM Microarrayer is a piezoelectric non-contact microarrayer with optical camera that manufactures high quality biochips by spotting various kinds of biomaterials uniformly with micro-spot size on 25mm x 75mm substrate. The camera that allows to check the shape of the microarray substrate is equipped, allowing researchers to dispense the samples at the correct position after presetting spot points. (Up to 18 slides (25mm x 75mm) can be placed on the workstation.) High-quality DNA chips, protein chips and bio-chips can be produced by using OptiSpot^TM Microarrayer.

• piezoelectric non-contact microarrayer
• Micro-circle pattern recognition of the substrate using camera attached by the nozzle
• Included 1 nozzle, Multiple nozzles can be easily replaced
• Up to 18 substrate (25 mm x 75 mm)
• Drop Volume range : 10–60 nl or 5–60 nl
• Drop Viscosity range : 1–200 mPas or 0.5–500 mPas

• Microarray workstation
• Dispenser, Nozzle module
• Optical Microscope module
• X-Y-Z axis controler and microarray software
• PipeJet pipes
• Laptop

XactII microarrayer from LabNEXT(www.labnext.com) is a versatile instrument. It can be equipped for slide or plate printing. Changes in the configurations are done in the lab. The microarrayer software also allows using virtually unlimited variants of custom labware and substrates (custom holders needed). Xact microarrayer can use either LabNEXT Xtend or Xtend RM pins or pins from other vendors, giving options for selecting best deposition technology for a particular experiment.

• Compact, portable, fast and versatile
• Can be converted in the lab for glass slide or microplate printing
• Features all options available in the high-end systems - precision, humidification, sample cooling
• Low heat emission in the operational area
• Choice of microarray pins - proprietary or 3rd party vendors
• Prints up to 25x25 spot arrays on bottom of standard 96-well plates with Xtend metal-ceramic printing pins

• Printing Method: Contact printing. Proprietary head and printing pins are available. The system can accommodate heads from other vendors.
• Number of printing pins: 1-16 in various patterns with the standard LabNEXT printing head. The control software can work with any printing pattern in case of using printing heads of other vendors.
• Pins spacing: 4.5 mm, 9 mm for 384 and 96 well plates correspondingly.
• Slides capacity: 14 slides. Any number of them can be used for pre-spotting.
• Source plates capacity: 1 plate. Source plates formats compatibility: 96, 384, 1536 plates.
• Slide locks: independent. The system can accommodate from 1 to 14 slides in any positions.
• Pins cleaning technology: fluid stream washing, vacuum drying.
• Print layouts: up to 3 identical microarrays at a slide. Pick-up and spotting repetitions.
• Throughput: 40 sec per print cycle (Print cycle: Wash, Dry, Pick-up, Pre-spot, Deposit at 13 slides). 384 well plate can be printed in 7-8 min with 16 pins.
• Environmental Control: on-board electronic humidifier (optional item). Maintains relative humidity inside the system cabinet in the range of 40-80% with 2% precision.
• Sample Cooling: Cooling source plate holder (optional item).