Bioruptor is used in analytical chemistry for many common procedures, including breaking of chemical bonds, formation
 of free radicals, polymersion and depolymerization of long-chain molecules, catalysis of reactions, nano carbonate tubes
 fabrication (e.g., reduction, alkylation, ester hydrolysis and acylation or aromatics), and preparation of catalyst and
 activation of catalyst.

 Many industrial applications require high volumes of liquids to be emulsified, dispersed or homogenized.
 This can be  accomplished through the use of a continuous flow cell for in-line processing.

 The pharmaceutical industry routinely uses sonification systems for processes such as sample premixing, dispersion
 and suspension, crack enteric coatings for dissolution testing, tablet pressing operations to reduce tablet size, and
 degassing and  homogenization of slurry in production.

 1. Better standardization

   • Allows standardized transfer of protocols between labs

   • Continuous rotation of tubes allows homogeneous distribution of energy

   • Temperature control improves preservation of samples (protein, DNA, epitopes,…)

   • Better reproducibility

 2. Better safety

   • No aerosol formation (Improved biosafety)

   • No risk of contamination between samples

   • No tedious manipulation of probes

   • Reduces “foaming”

   • Better preservation of samples

 3. Better throughput

   • Easy to operate

   • Sonicate up to 24 tubes in a single run

   • Different adaptors available to sonicate variable volumes

   • Use of standard disposable containers possible

   • Possible to sonicate small samples (down to 5 µl)

 • UCD-200

 • XL

 • Incubator

 • Twin  

 A generally accepted view is that ultrasound produces a gaseous cavitation in the liquid. This term describes the formation of  small bubbles from dissolved gases or vapours due to alteration of pressure. These bubbles are capable of resonance vibration  and produce vigorous eddying or micro streaming, which is sufficient to break cells. Also, the fragmentation of DNA takes place  as a consequence of mechanical stress or shear from the bubbles.

 With a probe sonicator, the micro streaming phenomenon is limited to the vicinity of the probe, whereas for the Bioruptor™, the  whole volume of water present in the tank is exposed to ultrasound energy.

 For 15 ml or 50 ml tubes, a metallic bar in contact with the sample facilitates the transfer of the ultrasounds inside the tubes.
 This  metallic bar is not a probe but it “reflects” the ultrasound originated from the water bath and improves the sample
 sonication  efficiency by a patented resonance system. As it is made of stainless steel it is not prone to corrosion.
 The figure below  schematizes the resonance of the ultrasound on the metallic bar.

 Diagenode Instrument Limited Warranty Information

 Diagenode is committed to delivering superior product quality and performance, supported by industry-leading global service
 and technical support teams.

 Diagenode' limited warranty for instruments and related components is set forth in the instrument user manual, in the limited  warranty statement that accompanies the instrument when it is shipped, and in Diagenode' terms of sale. Generally,
 Diagenode  warrants that all standard components of its instruments will be free of defects in materials and workmanship for a
 period of one (1) year from the date the warranty period begins, unless Diagenode' quotation or accompanying documentation
 states that a different warranty period or no warranty is provided. All warranty periods begin on the earlier of the date of
 installation. The instrument warranty is subject to certain exclusions, conditions, exceptions, and limitations.
 See those listed on request.

 Please contact Diagenode if you have any questions about our warranties or would like information about post-warranty support.

 Our team gives you the guarantee that at any time, you will receive all support and available information on any of our product
 as including contact details of other customers of the equipment.